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                Upstream Process Development Platform

                Service Introduction

                Media and feed screening platform
                Protein Quality Assessment (charge variants, glycosylationand aggregates)
                Stirred bioreactor process development
                Orbital Shaken bioreactor process development
                Perfusion process platform
                Intensified Fed-batch culture


                Stirred Cell Culture Platform

                TOP cloning bioreactor culturing evaluation, 3-15L scale culturing process development system.

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                Orbital Shaken Cell Culture Platform

                The novel bio-reacting and amplification system isjointly developed between Canton Biologics and the world's top bioreactor supplier Kuhner. It is more suitable for shear-sensitive protein manufacturing, providing a more stable culturing environment for easily degradable and easy-to-aggregate proteins. The system has excellent scale-up consistency from lab scale to batch manufacturing scale.

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                Downstream Process Development Platform

                • I. McAb Purification

                  Conventional affinity chromatography purification
                  Cost effective purification w/o affinitychromatography
                  Membrane chromatography purification
                • II. BsAb Purification

                  Aggregate removal
                  Product related impurities removal (mismatched and incomplete antibody fragments)
                  Mild purification condition to maximize protein stability
                • III. Recombinant protein purification

                  Diversified virus inactivation protocols
                  Appropriate protein capture strategies
                  Multiple protocols to maximize protein stability
                • Standard

                  Follow CDE and ICH Guideline
                  Utilize QbD development concepts
                  Apply HTPD and DOE tools
                • Technology

                  Chomatography techniques
                  Filtering technology
                  Virus inactivation/removal technology
                • Advantages

                  Recombinant protein purification
                  Bispecific antibody purification
                  Maximum protein stability
                      


                Liquid Formulation Development Platform

                Liquid Formulation Development Platform

                Rich project experience and strong regulatory track record
                High-throughput analytical technology for fast formulation screening
                Particle broad-spectrum detection

                Lyophilization Formulation Development Platform

                Quick solution to develop stable formulation
                Lyophilization process development
                Testing of critical formulation temperature
                Determination of water content

                Inhalation Formulation Development Platform

                Innovative delivery of inhaled biologics
                Inhalation formulation development
                Nebulizer screening
                Inhaled aerosol characterization
                Contact Us

                Please Contact Us for Further Service Details and Quotations!